| 发明名称 |
TARGETED ADENOVIRUS VECTORS |
| 摘要 |
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention generates an adenovirus with modified fiber gene using a two-plasmid rescue system for derivation of adenoviral fiber recombinants.
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| 申请公布号 |
WO9720575(A8) |
申请公布日期 |
2000.07.13 |
| 申请号 |
WO1996US19454 |
申请日期 |
1996.12.06 |
| 申请人 |
THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION |
发明人 |
CURIEL, DAVID |
| 分类号 |
C12N15/09;A61K31/522;A61K38/00;A61K39/235;A61K48/00;A61P35/00;C07K14/075;C07K16/08;C12N7/00;C12N7/02;C12N15/861;(IPC1-7):A61K39/235 |
主分类号 |
C12N15/09 |
| 代理机构 |
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