Carbapenems, process of their preparation, intermediates for their preparation, those carbapenems used for treating infections and pharmaceutical preparations

摘要

In the present invention there are disclosed carbapenems of the general formula I in which Re1 represents 1-hydroxyethyl group, 1-fluoroethyl group or hydroxymethyl group, Re2 represents a hydrogen atom or alkyl group containing 1 to 4 carbon atoms, Re3 represents a hydrogen atom or alkyl group containing 1 to 4 carbon atoms, Re4 and Re5 that can be the same or different are selected from a group comprising a hydrogen atom, a halogen atom, a cyano group, an alkyl group containing 1 to 4 carbon atoms, a nitro group, a hydroxy group a carboxyl group an alkoxyl group containing 1 to 4 carbon atoms, an alkoxycarbonyl group containing 1 to 4 carbon atoms in the alkoxy moiety, an aminosulfonyl group, an alkylaminosulfonyl group containing 1 to 4 carbon atoms in the alkyl moiety, dialkylaminosulfonyl group containing 1 to 4 carbon atoms in the alkyl moiety, a carbamoyl group, alkylcarbamoyl group containing 1 to 4 carbon atoms in the alkyl moiety, dialkylcarbamoyl group containing 1 to 4 carbon atoms in the alkyl moiety, a trifluoromethyl group, a sulfonic acid group, an amino group, an alkylamino group containing 1 to 4 carbon atoms in the alkyl moiety, dialkylamino group containing 1 to 4 carbon atoms in the alkyl moiety, an alkanoylamino group containing 1 to 4 carbon atoms in the alkanoyl moiety, alkanoyl-A-alkylamino group containing 1 to 4 carbon atoms in the alkanoyl moiety and 1 to 4 carbon atoms in the alkyl moiety, an alkanesulfonamide group containing 1 to 4 carbon atoms in the alkane moiety and alkyl-S-(O)in group containing 1 to 4 carbon atoms in the alkyl moiety, wherein a is 0, 1 or 2 with the proviso consisting in that in position ortho to the bond to -NRe3- neither hydroxy group nor carboxyl group is present, or pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof. In the present invention there are also claimed a process for preparing the above specified compounds, intermediates used in their preparation, their use as therapeutic agents as well as pharmaceutical compositions in which these compounds are comprised.