发明名称 |
Co-precipitates of adenovirus with metal salts |
摘要 |
The present invention provides co-precipitates of metal salts and adenoviral vectors containing a transgene. The co-precipitates of the invention exhibit increased efficiency of gene transfer to a target cell relative to adenoviral vectors alone. Methods of making and using the co-precipitates are also provided. A method of delivering cystic fibrosis transmembrane conductance regulator to an individual with CF utilizing a co-precipitate of cationic molecules and adenoviral vectors containing a transgene encoding a CFTR protein is provided.
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申请公布号 |
US6086870(A) |
申请公布日期 |
2000.07.11 |
申请号 |
US19980082510 |
申请日期 |
1998.05.21 |
申请人 |
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
WELSH, MICHAEL J. |
分类号 |
A61K48/00;C07K14/47;C12N15/12;C12N15/861;C12N15/87;(IPC1-7):A61K48/00 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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