发明名称 |
Use of imidazole and indole compounds as inhibitors of nitric oxide synthase |
摘要 |
Imidazole and indole compounds were found to inhibit neural nitric oxide synthase (bNOS) activity. Nortopsentin-C inhibited bNOS as well as calcineurin activities suggesting that its actions are directed against calmodulin, a co-factor common to these two enzymes. Two indole compounds, as well as dragmacidin-D, inhibited bNOS, but not calcineurin, activity. Murine macrophage viability and induced NOS (iNOS) activity in cultured cells was also unaffected by these compounds.
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申请公布号 |
US6087363(A) |
申请公布日期 |
2000.07.11 |
申请号 |
US19990356171 |
申请日期 |
1999.07.16 |
申请人 |
HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC. |
发明人 |
LONGLEY, ROSS E.;ISBRUCKER, RICHARD A.;WRIGHT, AMY E. |
分类号 |
A61K31/4178;A61K31/497;(IPC1-7):A61K31/495 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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