Device and method for analyzing tumor cell invasion of an extracellular matrix

摘要

PCT No. PCT/US96/01842 Sec. 371 Date Mar. 25, 1997 Sec. 102(e) Date Mar. 25, 1997 PCT Filed Feb. 9, 1996 PCT Pub. No. WO96/24661 PCT Pub. Date Aug. 15, 1996A device for analyzing the in-vitro growth properties of cells is disclosed. The device comprises an upper and lower chamber separated by a growth substrate interface comprising submucosa, preferably tunical submucosa, from a warm-blooded vertebrae. Methods for culturing eukaryotic cells and studying their growth characteristics, including the invasive growth characteristics of tumor cells, on the submucosal matrix are described.