Heterocyclyl-ergoline derivatives as 5-HT1A receptor ligands

摘要

PCT No. PCT/EP97/00582 Sec. 371 Date Aug. 17, 1998 Sec. 102(e) Date Aug. 17, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/30050 PCT Pub. Date Aug. 21, 1997Ergoline derivative having formula (I) wherein R1 is hydrogen atom or C1-4 alkyl group; R2 is hydrogen, chlorine, or bromine atom, methyl or C1-4 alkylthio group; n is 0, 1 or 2; the substituent at position 8 is in alpha or beta configuration; Het represents an aromatic 5-membered heterocyclic ring, said ring having three heteroatoms which are the same or different and which are selected from the group consisting of sulfur, oxygen and nitrogen atom and X is hydrogen, chlorine or bromine or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof are active at the Central Nervous System level. A process for their preparation is also described, as are pharmaceutical compositions containing them.