| 摘要 |
<p>Compounds of the formula (I) in which individual constituents have the meaning given in the Claims. A process for the production of said compounds which can be characterised in that the compound of the general formula (II), wherein R1 to R9, Ra, Rb, X, Z, m and n have the significance given in the Description and A is hydroxy or amino, reacts: a) with an isocyanate of the formula R10NCO or a carbamoyl chloride of the formula (R10R11)NCOCI, wherein R10 and R11 have the significance given in the Claims or b) with phosgene and thereafter with an alcohol of the formula R10OH; or with a chloroformate of the formula R10OC(O)CI, wherein R10 has the significance given in the Claims and, if desired, substituents present in the thus-obtained compound of the formula (I) are modified and, if desired, a compound of the formula (I) is converted into a pharmaceutically usable salt. Also disclosed are pharmaceuticals containing these compounds and common carriers and auxiliaries. The use of the aforementioned compounds for the production of medicaments usable for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.</p> |
