发明名称 Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds.
摘要 This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres represented by formula (I), their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth. In said formula, n is 1-3; X is either O or S; R1 is selected from the group consisting of C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, aryl, heteroaryl, carboncycle, or heterocycle; D is a bond, or a C1-C10 straight or branched chain alkyl, C2-C10 alkenyl or C2-C10 alkynyl; R is as defined in the application.
申请公布号 ZA9811063(B) 申请公布日期 2000.07.07
申请号 ZA19980011063 申请日期 1998.12.03
申请人 GUILFORD PHARMACEUTICALS INC. 发明人 GREGORY S. HAMILTON;MARK H. NORMAN;YONG-QIAN WU
分类号 A61K;B25B21/00;C07D 主分类号 A61K
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