发明名称 |
DEVICES AND METHODS FOR ANALYSIS OF NON-IONIC SOLUTES |
摘要 |
This invention relates to devices and methods for detecting and monitoring the concentration, level or amount of a target molecule in solution. More particularly, the invention is directed to sensors that evaluate changes in conductivity produced by the reaction of a target molecule with a sensor composition. The invention is particularly well suited for determining the concentration of carbohydrate compounds in solution, such as diol compounds, preferably biologically significant cis-diols such as various sugars including glucose. The invention also encompasses sensors for determining the total or relative amount of target molecule in a sample, particularly a biological sample such as blood, urine, or other biological fluids. A laminated sensor of the invention comprises a sensor composition applied to a metal electrode, such as an interdigitated gold electrode on a non-conductive support. The sensor composition and electrode are and preferably encapsulated by a bipolar membrane. In a preferred embodiment, the sensor composition is a blend of a boronic acid polymer and a non-ionogenic hydrogel matrix.
|
申请公布号 |
WO0010007(A9) |
申请公布日期 |
2000.07.06 |
申请号 |
WO1999US18615 |
申请日期 |
1999.08.16 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY;ARNOLD, FRANCES, H.;MICHAELS, ALAN, S.;ZHENG, WEIGONG |
发明人 |
ARNOLD, FRANCES, H.;MICHAELS, ALAN, S.;ZHENG, WEIGONG |
分类号 |
G01N27/30;G01N33/487;(IPC1-7):G01N33/487;A61B5/00 |
主分类号 |
G01N27/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|