| 摘要 |
<p>Remedies for pain which contain as the active ingredient compounds having both of an opioid ν receptor agonist activity and a dopamine D2 receptor antagonist activity. The compounds having both of these activities exert a potent morphine-like analgetic effect but cause no mental dependency. Moreover, these compounds can regulate side effects. In particular, novel compounds represented by general formula (I) and pharmacologically acceptable salts thereof have both of the opioid ν receptor agonist activity and the dopamine D2 receptor antagonist activity and are useful as remedies for pain with regulated side effects.</p> |
