PROCESS FOR THE PREPARATION OF PAROXETINE ACETATE AND ANALOGUES THEREOF
摘要
The present invention relates to a new process for preparing pharmaceutically active compounds and intermediates therefor. The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3',4'-methylenedioxyphenoxymethyl)-piperidine (paroxetine) is an important compound having antidepressant and anti-Parkinson properties. This compound is used in therapy as the hydrochloride salt to treat inter alia depression, obsessive compulsive disorder (OCD) and panic. There is described a process for the preparation of paroxetine acetate and analogues thereof.
申请公布号
WO0039090(A1)
申请公布日期
2000.07.06
申请号
WO1999GB04358
申请日期
1999.12.22
申请人
SMITHKLINE BEECHAM PLC;CRAIG, ANDREW, SIMON;JONES, DAVID, ALAN;MAN, JOHN