PROCESS FOR THE PREPARATION OF AN ACETATE SALT OF PAROXETINE OR PAROXETINE ANALOGUES

摘要

The present invention relates to a new process for the preparation of an acetate salt of a compound of formula (1) in which R<1> is a substituted phenyl group, preferably 3,4-methylenedioxyphenyl; the process comprising treating a solution of the compound of formula (1) with acetic acid and a co-solvent. The (-) trans isomer of 4-(4'-fluorophenyl)-3-(3',4'-methylenedioxyphenoxymethyl)-piperidine (paroxetine) is an important compound having antidepressant and anti-Parkinson properties. This compound is used in therapy as the hydrochloride salt to treat inter alia depression obsessive compulsive disorder (OCD) and panic.