METHOD FOR MANUFACTURING TAXOL USING SODIUM BENZOATE

摘要

PURPOSE: A method for manufacturing taxol is provided which accumulates high concentration of taxol by culturing Pestalotia heterocornis in the medium including high concentration of sodium benzoate. CONSTITUTION: Taxol if formula (1) shows an excellent anticancer activity, therefore, is used for developing medical supplies. The taxol-producing bacteria such as Pestalotia heterocornis KCTC 0340BP are cultured in the medium including sodium benzoate during the production of taxol. The production of taxol is increased from 30 μg to 100 μg based on 1 liter of medium by adding 0.1-10 g(desirably 0.3-3 g) of sodium benzoate into 1 liter of medium.