METHOD FOR MANUFACTURING TAXOL USING METAL ION

摘要

PURPOSE: A method for manufacturing taxol is provided which accumulates high concentration of taxol by culturing mycete producing taxol in medium including high concentration of metal ions. CONSTITUTION: Taxol shows an excellent anticancer activity therefor, is used for developing medical supplies. The taxol-producing bacteria such as Pestalotia heterocornis KCTC 0340BP are cultured in the medium including metal ions such as iron, manganese, and magnesium during the production of taxol. The production of taxol is increased from 30 μg to 100 μg based on 1 liter of medium by adding 0.05-50g of metal ion into 1 liter of medium. More than one ion among iron, manganese, and magnesium are available as metal ion.