PREPARATION OF 1-BUTYL-4-PIPERIDINYLMETHYLAMINE

摘要

PURPOSE: A process for the preparation of 1-butyl-4-piperidinylmethylamine which is useful as an intermediate in the manufacture of compounds having pharmacological activity. CONSTITUTION: A process for the preparation of 1-butyl-4-piperidinylmethylamine, which process comprises: i) the reaction of isonipecotamide and 1-bromobutane to give the N-butyl derivative of isonipecotamide; followed by ii) reduction with LiAlH4, characterized in that the reactions i) and ii) are carried out in toluene as solvent.