Immunoassay for detection of mutant P53 polypeptide in serum

摘要

PCT No. PCT/US92/00878 Sec. 371 Date Jul. 28, 1993 Sec. 102(e) Date Nov. 23, 1993 PCT Filed Jan. 31, 1992The invention provides a method for diagnosing in a subject a neoplastic condition which comprises (a) obtaining from the subject a sample of a biological fluid; and (b) detecting the presence in the sample of a mutant p53 polypeptide encoded by an activated p53 oncogene, the presence of the mutant p53 polypeptide in the sample indicating that the subject has the neoplastic condition.