| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing an UCN-01, capable of simply and efficiently producing the UCN-01 having an anti-tumor action and an anti- bacterial action by acidifying a solution containing an UCN-02. SOLUTION: This method for producing the UCN-01 of formula II comprises acidifying a solution containing UCN-02 of formula I to isomerize the UCN-02 into the UCN-01 and then recovering the UCN-01 from the solution. The solution containing the UCN-02 includes a solution obtained by oxidizing staurosporine in a solution comprising dimethyl sulfoxide and an alkali aqueous solution. The isomerization reaction is carried out, for example, by adding water to the solution containing the UCN-02 to give a water concentration of >=90%(V/V), and then acidifying the solution with hydrochloric acid to change into a solution of pH 2-2.5. The concentration of the UCN-02 in the reaction solution is preferably 5-10 g/L. When the UCN-01 is contained in the reaction solution, the total concentration of the UCN-01 and the UCN-02 is preferably adjusted to the above concentration. After the reaction is finished, the reaction solution is adjusted to pH 7 or higher to deposit the UCN-01.
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