摘要 |
PROBLEM TO BE SOLVED: To efficiently deprotect an amino group and a hydroxy group protected with an alkynylmethyloxycarbonyl group by bonding the amino group and the hydroxy group with the alkynylmethyloxycarbonyl group, by allowing a strong acid to act on the protected groups in the presence of a metal or a metal complex to isolate the amino group or the hydroxy group. SOLUTION: For example, in the reaction formula (R is H, an alkyl or the like, R1 is a sugar derivative or the like; R2 and R3 are each H, an amino acid derivative or the like), when an alkynylmethyl chlorocarbonate of structure 1 is reacted with an alcohol 2a or an amine 2b, a corresponding alkynylmethyloxycarbonyl derivative 3a or 3b is formed, and the hydroxy group and the amino group is protected. When a strong acid such as trifluoroacetic acid(TFA) is allowed to act on the obtained alkynylmethyloxycarbonyl derivative 3a or 3b in the presence of a cobalt carbonyl complex, the deprotection is rapidly and efficiently carried out to regenerate the original alcohol 2a or amine 2b.
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