| 发明名称 |
3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesionmediated by vla-4 |
| 摘要 |
Compounds of formula (I) which inhibit leukocyte adhesion mediated by interaction of the alpha 4 beta 1 integrin (VLA-4) with its counterreceptor VCAM-1, and their use for the treatment of inflammatory and autoimmune diseases. |
| 申请公布号 |
AU2357600(A) |
申请公布日期 |
2000.07.03 |
| 申请号 |
AU20000023576 |
申请日期 |
1999.12.10 |
| 申请人 |
AMERICAN HOME PRODUCTS CORPORATION |
发明人 |
LOUIS JOHN LOMBARDO;JOAN E. SABALSKI |
| 分类号 |
C07D295/12;A61K31/198;A61K31/4045;A61K31/4174;A61K31/4406;A61K31/4409;A61K31/445;A61K31/455;A61K31/495;A61P1/00;A61P3/10;A61P9/10;A61P11/06;A61P25/28;A61P29/00;A61P35/04;A61P43/00;C07C229/36;C07C229/46;C07C271/44;C07D209/14;C07D209/16;C07D211/62;C07D213/36;C07D213/38;C07D213/81;C07D213/82;C07D233/64;C07D295/135;C07D295/18;C07D295/185;C07D295/20;C07D295/205 |
主分类号 |
C07D295/12 |
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