发明名称 |
IDENTIFICATION, PURIFICATION AND USES OF LECZYMES AND CARBOHYDRATE LIGANDS |
摘要 |
<p>The present invention provides a substantially purified carbohydrate ligand that specifically binds to a leczyme. The invention also provides methods to identify a carbohydrate ligand that specifically binds to a leczyme or a leczyme that specifically binds to a carbohydrate ligand. The invention further provides methods to identify a peptide that binds to the carbohydrate ligand binding site of a leczyme. The present invention provides methods to isolate a carbohydrate ligand or a leczyme and to identify a carbohydrate ligand or a leczyme that modifies the function of a cell and to obtain such functionally modified cells. The invention further provides methods to modify a cell to express a carbohydrate ligand by introducing an expression vector encoding a leczyme into the cell. The invention also provides methods to modulate the immune response to an antigen by administering the antigen and a carbohydrate ligand. In addition, the invention further provides methods to treat a disease state involving a leczyme by administering a carbohydrate ligand that binds the leczyme or by administering a leczyme that has a similar binding specificity to the leczyme involved in the disease state. The invention further provides methods to diagnose a genetic basis for hemochromatosis by detecting a mutation in a class I MHC molecule that reduces it's ability to associate with beta<SUB>2 </SUB>microglobulin.</p> |
申请公布号 |
EP0820469(A4) |
申请公布日期 |
2000.06.28 |
申请号 |
EP19950943382 |
申请日期 |
1995.12.06 |
申请人 |
ROTHENBERG, BARRY E. |
发明人 |
ROTHENBERG, BARRY E. |
分类号 |
G01N33/53;A61K31/70;A61K31/715;A61K35/76;A61K38/00;A61K38/43;A61K38/45;A61K39/39;A61K45/00;A61K47/48;A61K48/00;A61P3/00;A61P29/00;A61P31/00;A61P37/04;C07H1/08;C07K14/47;C07K14/74;C12N5/08;C12N9/00;C12N15/09;C12Q1/68;G01N33/566;G01N33/573;(IPC1-7):C07K14/74;C08B37/00;C12N9/24;C12Q1/48;A61K39/00;A61K38/46 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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