发明名称 |
New medical use of gene and vector encoding a multisubstrate deoxyribonucleosidase |
摘要 |
By inserting a DNA or RNA sequence comprising a subsequence showing a homology of at least 60%, preferably at least 80%, and most preferably at least 90% of the DNA sequence of SEQ. ID. NO. 1 into a cell, that cell will obtain a broad specificity for changing nucleoside analog prodrugs to active drugs by phosphorylation. Likewise this changement will occur at a high catalytic rate. Preferably the DNA sequence is inserted into the cell by transformation with a suitable virus or another suitable vector. Such viruses and vectors also constitute a part of the present invention. |
申请公布号 |
AU2018500(A) |
申请公布日期 |
2000.07.03 |
申请号 |
AU20000020185 |
申请日期 |
1999.12.10 |
申请人 |
ANNA KARLSSON |
发明人 |
ANNA KARLSSON;MAGNUS JOHANSSON |
分类号 |
C12N15/09;A61K35/76;A61K38/45;A61K48/00;A61P35/00;A61P35/02;A61P43/00;C12N7/00;C12N9/12;C12N15/54;C12P19/30 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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