| 发明名称 |
Humanized chimeric antibodies against ganglioside GD3 |
| 摘要 |
<p>The present invention discloses a process for the production of humanized chimera antibody, wherein the chimera antibody is produced easily without changing any of the amino acids of its mouse antibody variable region. The invention relates to humanized chimera antibodies obtainable by the claimed process and being reactive with ganglioside GD3, to transformants capable of producing said humanized chimera antibodies, to pharmaceutical compositions comprising said humanized chimera antibodies, and the use of these antibodies for treating cancer.</p> |
| 申请公布号 |
EP1013761(A2) |
申请公布日期 |
2000.06.28 |
| 申请号 |
EP19990124345 |
申请日期 |
1992.09.18 |
| 申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
SHITARA, KENYA;HANAI, NOBUO;HASEGAWA, MAMORU;MIYAJI, HIROMASA;KUWANA, YOSHIHISA |
| 分类号 |
A61K36/00;A61K38/00;A61P35/00;C07K7/06;C07K7/08;C07K14/00;C07K16/00;C07K16/18;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N5/10;C12N15/00;C12N15/09;C12N15/12;C12N15/13;C12N15/62;C12P21/08;C12R1/91;(IPC1-7):C12N15/12;C12N15/64;A61K39/395 |
主分类号 |
A61K36/00 |
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