发明名称 |
Method of preparing 16-dehydro vitamin D compounds |
摘要 |
The invention relates to a new method of preparing 16-dehydro vitamin D compounds having formula I wherein: R has the epi-configuration or the normal configuration and represents straight or branched C1-6-alkyl, C2-6-alkenyl, C3-6-cycloalkyl, or an aromatic group optionally substituted with halogen, C1-3-alkyl or alkoxy, Z is a saturated or unsaturated straight hydrocarbon group or oxahydrocarbon group containing 3-6 C-atoms which may be substituted with OH, F, alkyl (C1-3) or cycloalkyl (C3-5), R1 is hydrogen or an hydroxy protecting group, R2 is hydrogen or hydroxy, and A and B represent hydrogen or methyl, or together form the methylene group, to the new compounds having this formula and to new intermediates obtainable according to this process.
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申请公布号 |
US6080878(A) |
申请公布日期 |
2000.06.27 |
申请号 |
US19980067903 |
申请日期 |
1998.04.29 |
申请人 |
DUPHAR INTERNATIONAL RESEARCH B.V. |
发明人 |
DE LOS ANGELES REY, MARIA;MOURINO, ANTONIO;FERNANDEZ-GACIO, ANA;FALL, YAGAMARE;HALKES, SEBASTIANUS J.;HALKES, KOEN M.;VAN DE VELDE, JAN-PAUL;ZORGDRAGER, JAN |
分类号 |
A61K31/59;A61P11/00;A61P17/00;A61P29/00;A61P35/00;A61P37/00;C07C35/27;C07C49/665;C07C401/00;(IPC1-7):C07C401/00 |
主分类号 |
A61K31/59 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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