发明名称 |
Therapeutic methods for benzodiazepine derivatives |
摘要 |
This invention provides an antibody with high affinity for single-stranded DNA, low or no affinity for double-stranded DNA, and capable of specifically binding a DNA hairpin and the hybridoma cell lines which produces these monoclonal antibodies. A chimeric mouse comprising these hybridoma cell lines and a histocompatible mouse is further provided. A method for screening for an agent which will inhibit anti-DNA antibody.DNA binding. One such agent is a benzodiazepine derivative. This invention therefore provides a method of inhibiting the binding of an anti-DNA antibody to its DNA ligand in a sample by contacting the sample with an effective amount of a benzodiazepine derivative.
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申请公布号 |
US6080588(A) |
申请公布日期 |
2000.06.27 |
申请号 |
US19970881037 |
申请日期 |
1997.06.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
GLICK, GARY D. |
分类号 |
A61K31/5513;A61K38/00;C07K16/18;(IPC1-7):G01N33/564 |
主分类号 |
A61K31/5513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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