摘要 |
A pyrimidine compound of the formula [I]wherein R1 is H, C1-C4 lower alkyl, halogen atom, -OH, C1-C4 lower alkoxy, C1-C6 hydroxy(lower)alkoxy or -NH2; R2 is H, -NH2 or -NHCOCH3; R3 is -NR5(CH2)i-CH2OH; R4 is H, halogen atom, -NH2, -CN, -CHO, -CH2OH, -COOH, -CH2NH2, -CONH2 or -CH=N-A wherein A is -OH, C1-C4 lower alkyl or C1-C4 lower alkoxy; R5 is H or C1-C4 lower alkyl; and i is an integer of 1 to 4, and an anti-rotavirus agent comprising, as an active ingredient, a compound of the formula [I] wherein R3 is a group selected from the following: The novel pyrimidine compound of the present invention and related derivatives thereof have superior anti-rotavirus action and are useful for the prophylaxis and treatment of rotaviral diseases.
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申请人 |
NIPPON SHOJI KAISHA LTD. |
发明人 |
HISAKI, MASAKATSU;OHTA, YOICHIRO;KAWANISHI, KENJI;ICHIGOBARA, YASUKO;IWAKURA, FUZUKI;AZUMA, MASANOBU;SUZUTANI, TATSUO;NODE, MANABU;NISHIDE, KIYOHARU |