| 摘要 |
PROBLEM TO BE SOLVED: To provide a hyaluronic acid gel which can be used as a biocompatible material with a long residence time in the living body, without using any chemical crosslinker or chemical modifier and without forming a composite with a cationic polymer for the best use of the feature, i.e., the excellent biocompatibility inherent in hyaluronic acid. SOLUTION: The process for producing a hyaluronic acid gel hardly soluble in a neutral aqueous solution comprises freezing an acidic hyaluronic acid solution made by using a mixture of a polar organic solvent and water as the solvent and having a pH of 3.5 or lower, and then thawing the solution. The hyaluronic acid gel is formed from an acidic hyaluronic acid solution of which the concentration of hyaluronic acid is at least 5 wt.%, in which the solvent used comprises a mixture of a polar organic solvent and water, and which contains an acid component in an amount at least equimolar to that of the carboxy groups of hyaluronic acid.
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