Methods for discovering ligands

摘要

PCT No. PCT/GB95/00209 Sec. 371 Date Oct. 2, 1996 Sec. 102(e) Date Oct. 2, 1996 PCT Filed Feb. 1, 1995 PCT Pub. No. WO95/21265 PCT Pub. Date Aug. 10, 1995A method of identifying one or a combination of ligands, e.g. oligonucleotides or analogues, that interact specifically with a target, e.g. a DNA or an RNA molecule having a secondary or tertiary structure. One ligand may be pre-reacted to open up the target for interaction with other ligands forming an array on a solid surface.