ANALOGUES OF LHRH ALLOWING INCREASED ANTIGENICITY THROUGH CONJUGATION

摘要

An analogue of lutenising hormone-releasing hormone (LHRH) having the amino acid sequence: pGlg-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Gly-Y-Z wherein X represents Gly or a D-amino acid, Y represents one or more amino acid residues, which may be the same or different, and Z represents Cys or Tyr, such that the solution conformation of said analogue is substantially similar to that of native LHRH. The analogues may be used to prepare vaccines for reducing fertility in mammals.