| 摘要 |
PURPOSE: A prophylactic and therapeutic agent of muscle tissue degeneration is provided, which is capable of inhibiting or improving necrosis, fibrosis, calcification and the like of muscle tissues. CONSTITUTION: The prophylactic and therapeutic agent of muscle tissue degeneration of the present invention contains the quinoline compound of the formula(I) or a pharmaceutically acceptable salt thereof as an active ingredient. In the formula(I), R1 is lower alkyl, R2 and R3 are the same or different and each is independently hydrogen atom, R4 is hydrogen atom, R5 is hydrogen atom or chlorine atom, R6 is -COOH,-COOR12, R7 and R8 are the same or different and each is independently hydrogen atom, fluorine atom, chlorine atom or lower alkyl, X is nitrogen atom and Y is CH. The quinoline compound of the formula(I) or a pharmaceutically acceptable salt thereof as an active ingredient is formulated to have a dosage form using a pharmaceutically acceptable carrier and the like, into a solid preparation (tablet, granule, capsule, powder and the like), a liquid preparation (liquid, suspension, syrup, emulsion, lemonade and the like) and the like and used as a pharmaceutical preparation.
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