| 摘要 |
PURPOSE: Provided are compounds useful as medicines and use of the compound. Specifically, pharmaceutical compositions containing a chromen-3-carboxyl acid derivative, pharmaceutical compositions for use as an endothelin receptor antagonist containing the same; pharmaceutical compositions for use as a peripheral circulation insufficiency-improving agent containing the same; and a novel chromen-3-carboxyl acid derivative are provided. Further, a pharmaceutical composition for use as a macrophage foam cell formation inhibitor containing an endothelin antagonist is provided. CONSTITUTION: Provided is a compound of the formula (I): wherein R(1), R(2), R(3)and R(4) are each independently hydrogen, optionally substituted alkyl, hydroxy, optionally substituted alkoxy or the like, R(5) is optionally substituted alkyl, optionally substituted aryl, optionally substituted heterocyclic or the like, R(6) is hydrogen, optionally substituted alkyl or the like, R(7) is hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heterocyclic or the like, A is S or O and a broken line represents presence or absence of a bond, pharmaceutically acceptable salt or hydrate thereof and a pharmaceutical composition or a pharmaceutical composition for use as an endothelin receptor antagonist, a peripheral circulation insufficiency-improving agent or a macrophage foam cell formation inhibitor comprising the compound.
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