N-FORMYL-O-ACYL-THREO- AND ERYTHRO-DL-BETA-PHENYLSERINE ETHYL ESTERS AND PROCESS FOR PREPARING THEREOF

摘要

This invention presents a convenient preparatory method allowing synthesis of N,O-diacyline beta-phenyl serine structures with different acyl groups. In the system formic acid - hydrogen fluoride in the on-going migration of N-acyl beta-phenyl serine combinations of the acylic N > O is accompanied by N-formyl. Using this method, new N-formyl-O-acyl-threo- and erythro-DL-beta-phenylserine ethyl esters are synthesised from N-acyl-threo and erythro-DL-beta-phenyl serine ethyl esters in good yield after affecting them with 1.5% hydrogen fluoride solution in formic acid.