发明名称 |
METHOD OF TREATMENT OF ATTENTION-DEFECIT/HUPERACTIVITY DISORDER |
摘要 |
1. A use of a compound of the formula wherein X = C1-C4 alkylthio, and Y = C1-C4 alkyl or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof for the treatment of attention-deficit/huperactivity disorder of duloxetine. 2. A use of claim 1 wherein the predominantly inattentive type of attention-deficit/hyperactivity disorder is to be treated. 3. A use of claim 1 wherein the predominantly hyperactive-impulsive type of attention-deficit/hyperactivity disorder is to be treated. 4. A use of claim 1 wherein the combined type of attention-deficit/hyperactivity disorder is to be treated. 5. A use of claim 1 wherein the patient to be treated is a child. 6. A use of claim 1 wherein the patient to be treated is an adolescent. 7. A use of claim 1 wherein the patient to be treated is an adult. 8. A use of a compound of the formula wherein X = C1-C4 alkylthio, and Y = C1-C4 alkyl or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of attention-deficit/hyperactivity disorder of duloxetine. 9. A use of claim 8 wherein the predominantly inattentive type of attention-deficit/hyperactivity disorder is to be treated. 10. A use of claim 8 wherein the predominantly hyperactive-impulsive type of attention-deficit/hyperactivity disorder is to be treated. 11. A use of claim 8 wherein the combined type of attention-deficit/hyperactivity disorder is to be treated. 12. A use of claim 8 wherein the patient to be treated is a child. 13. A use of claim 8 wherein the patient to be treated is an adolescent. 14. A use of claim 8 wherein the patient to be treated is an adult. 15. A use of a pharmaceutical composition comprising a pharmaceutical carrier and a compound of the formula I wherein X = C1-C4 alkylthio, and Y = C1-C4 alkyl or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof for the treatment of attention-deficit/hyperactivity disorder. 16. A composition of claim 15 wherein the predominantly inattentive type of attention-deficit/hyperactivity disorder is to be treated. 17. A composition of claim 15 wherein the predominantly hyperactive-impulsive type of attention-deficit/hyperactivity disorder is to be treated. 18. A composition of claim 15 wherein the combined type of attention-deficit/hyperactivity disorder is to be treated. 19. A composition of claim 15 wherein the patient to be treated is a child. 20. A composition of claim 15 wherein the patient to be treated is an adolescent. 21. A composition of claim 15 wherein the patient to be treated is an adult. 22. A use of any one of claims 1-14 wherein the compound is N-methyl-3-(2-methylthiophenoxy)-3-phenylpropylamine or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. 23. A use of any one of claims 15-21 wherein the compound is N-methyl-3-(2-methylthiophenoxy)-3-phenylpropylamine or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. |
申请公布号 |
EA000856(B1) |
申请公布日期 |
2000.06.26 |
申请号 |
EA19980000152 |
申请日期 |
1996.07.18 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
HEILLIGENSTEIN, JOHN, H.;LAGUZZA, BENNETT, C.;PAUL, STEVEN, M.;TOLLEFSON, GARY, D. |
分类号 |
A61K31/00;A61K31/135;A61K31/138;A61K31/381;A61P25/00;A61P25/02 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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