| 摘要 |
The present invention pertains to the field of medicine, more precisely to that of pharmacology, and essentially relates to biologically active synthetic diazoles that consist of 2-R-5-amino-1,3,4-thiadiazole derivatives. These substances are mainly intended for use in medical practice for treating chlamydiae-mediated viral diseases as well as diseases resulting in immunodeficiency, including malignant tumours. The purpose of the present invention is to create new chemical compounds which have a high antiviral and an anti-microbial (anti-chlamydia) activity, which stimulate the production of endogenous interferons in the organism and which also have anti-aggregating, analgesic and psycho-depressive actions. This invention involves synthesising a new group of substances that consist of 2-R-5-amino-1,3,4-thiadiazole derivatives of general formula (1) where R1 is selected from the group comprising alkyl, aryl and -CH2-CH2C(0)NH-N=CH-Z, provided that Z is aryl or piperonyl, while R2 is selected from the group comprising H and (a), provided that Y is aryl or heteroaryl. This invention further relates to general methods for producing these substances, to 4 examples of the synthesis of said substances, to the identification results of each of the 42 synthesised substances as well as to data concerning the experimental verification of the substance biological activity relative to known preparations used for the same purposes. |
