Assays for compounds which increase phospholipase a2 activity

摘要

A method of identifying a compound which increases the activity of a phospholipase A2 towards a given phospholipid substrate the method comprising determining whether the activity of phospholipase A2 towards the given substrate is increased in the presence of a compound compared to its activity in the absence of the same compound. A method of identifying a compound which increases the production or expression of phospholipase A2 in a cell the method comprising determining directly or indirectly whether the production or expression of phospholipase A2 in a cell is increased in the presence of a compound compared to its production or expression in the absence of the same compound. A method of treating a psychiatric or neurological disorder such as depression in a patient the method comprising administering an effective dose of a compound which increases the release of docosahexaenoic acid from brain membrane phospholipids. A method of identifying a compound which mimics the effect of docosahexaenoic acid on the glucocorticoid receptor the method comprising contacting the glucocorticoid receptor with a compound and determining whether the compound has substantially the same effect as docosahexaenoic acid on the glucocorticoid receptor.