| 摘要 |
PURPOSE: Provided is a new peptide derivative having the residue of 3-(4-thiazolyl or 5-thiazolyl)-alanine and having an effect of activating the central nervous system. Pharmaceutically acceptable salt, or hydrate thereof are also provided. The compounds are useful as a medicament. CONSTITUTION: Provided are a peptide derivative of the formula (I), its pharmaceutically acceptable salt, or hydrate thereof wherein A is 4-thiazolyl or 5-thiazolyl wherein the nitrogen in the thiazolyl ring may be quarternary nitrogen which is formed with optionally substituted alkyl or alkenyl, X is a bond, oxygen, or sulfur, m is an integer of 0 to 4, Y is optionally substituted alkyl, optionally substituted carboxy, cyano, or the substituent; wherein R(1) and R(2) are independently hydrogen or optionally substituted alkyl, or R(1) and R(2) taken together with may form a non-aromatic heterocyclic ring the adjacent nitrogen which may contain oxygen, nitrogen, or sulfur and may be substituted, Z is the substituent; wherein R(3) is hydrogen, optionally substituted alkyl, optionally substituted carboxy, or optionally substituted acyl, R(4) and R(5) are each independently hydrogen or optionally substituted alkyl, and W is -(CH2)n- wherein n is 0, 1, 2, or 3, oxygen, sulfur, or optionally substituted imino, or the substituent.
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