| 摘要 |
PURPOSE: Provided is Compounds useful for the treatment of conditions and diseases which are characterized by unwanted MP activity, potent inhibitors of metalloproteases, pharmaceutical compositions comprising such inhibitors and a method of treatment for metalloprotease related maladies. CONSTITUTION: The compounds of the invention are useful as inhibitors of metalloproteases, preferably a matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compound having a structure according to Formula (I). The inhibitors of the invention can be targeted to specific locations where the metalloprotease is accumulated by using targeting ligands. The compounds are relatively small, they are advantageously coupled to neutral carriers such as the conventionally used keyhole limpet hemocyanin (KLH) or serum albumin carriers.
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