| 摘要 |
Examples of the antagonist ligand of the RAR-gamma type include; 2-hydroxy-4-[7-(1-adamantyl)-6-benzyloxy-2-naphthyl]benzoic acid, 2-hydroxy-4-[7-(1-adamantyl)-6-(4-fluorobenzyl)oxy-2-naphthyl] benzoic acid, 2-hydroxy-4-[7-(1-adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzoic acid, 4-[7-(1-adamantyl)-6-methoxyethoxymethoxy-2-naphthyl]benzoic acid, 5-[7-(1-adamantyl)-6-benzyloxy-2-naphthyl]-2-thiophenecarboxylic acid. The agonist ligands of the RAR-alpha type are; 4-( (5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido)benzoic acid, and 2-hydroxy-4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro- naphthalene-2-carboxamido)-benzoic acid. The 'alpha'-RAR receptor-specific agonist ligand and the 'gamma'-RAR receptor-specific antagonist ligand can be used in the treatment of HIV, neurodegenerative diseases, myelodysplastic syndromes, ischaemic syndromes, liver diseases induced by toxins, alopecia, damage to skin due to UV light, lichen planus, atrophy of the skin, cataract or graft rejections.
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