Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor

摘要

Amidinoindoles and amidinoazoles of the formula 1: W and W3 are CH or N, W1 and W2 are C, CH and N, provided 0-2 of W-W3 are N; D and Da is H, C1-4 alkoxy, CN, C(=NR7)NR8R9, NHC(=NR7)NR8R9, NR8CH(=NR7), C(O)NR8R9 and (CH2)tNR8R9 provided one of D and Da is H and one W-W3 is N, Ja and Jb is substituted by -(CH2)n-Z-A-B. These compounds are used as inhibitors of factor Xa and thrombin.