发明名称 |
3-hydroxy-4-hydroxy amino substituted succinyl derivatives of tertiary leucine or phenylalanine which are inhibitors of the production of s-CD23 and the secretion of TNF |
摘要 |
The amide derivatives have the formula I: HONH-C(O)-CH(R)-CH(R1)-C(O)-NH-CH(R2)-C(O)-NHR3 wherein; R is OH, H, alkyl, alkenyl, alkynyl or aryl; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl and R3 is H, alkyl, alkynyl or aryl provided that if R1 is an optionally substituted phenyl or naphthyl then R is OH. A pharmaceutical composition thereof is useful as an inhibitor of the processing of TNF.
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申请公布号 |
NZ332628(A) |
申请公布日期 |
2000.06.23 |
申请号 |
NZ19970332628 |
申请日期 |
1997.05.06 |
申请人 |
SMITHKLINE BEECHAM PLC |
发明人 |
BAILEY, STUART;BUCKLE, DEREK RICHARD;FALLER, ANDREW;SMITH, DAVID GLYNN |
分类号 |
C07D317/36;A61K31/00;A61K31/16;A61K31/335;A61K31/34;A61K31/343;A61K31/357;A61K31/38;A61K31/381;A61K31/425;A61K31/428;A61K31/47;A61P29/00;A61P37/00;A61P43/00;C07C259/06;C07D215/12;C07D277/64;C07D307/79;C07D307/80;C07D333/54;C07D333/60;(IPC1-7):A61K31/425;C07D215/04;C07D333/72 |
主分类号 |
C07D317/36 |
代理机构 |
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代理人 |
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地址 |
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