| 摘要 |
The 2-oxo-azetidin-1-yl derivative has the formula I wherein: R1 is H or the corresponding pharmaceutically acceptable ester or pharmaceutically acceptable salt thereof; R2 and R3 are independently H or optionally substituted alkyl; X is X'-(CH2)m or an alkylene chain optionally interrupted by X'; X' is CO, CONR4, COO, CONR4CO, CONHCO or CH2O; R4 is H or alkyl; m is 0 to 12; Y is an optionally substituted aryl group. The 2-oxo-azetidin-1-yl has an absolute configuration (4R, SS). A pharmaceutical composition thereof is useful for treating atherosclerosis, diabetes, hypertension, angina pectoris, reperfusion stoke, sepsis, psoriasis or schizophrenia.
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