Injection formulations of avermectins and milbemycins based on castor oil

摘要

Injection formulations of avermectins and milbemycins based on castor oil are disclosed. Described are avermectins of general formula (I) in which R1 to R4 have the meanings as specified in the disclosure in Table 1 and X can be a single or double bond between the C22 and C23 positions (-C22R1-X-C23-R2-) and milbemycins of general formula (II) in which R1 to R4 have the meanings as specified in the disclosure in Table 2. The formulations have the general composition: 0.1 to 10% m/v of an avermectin and/or milbemycin in a solvent mixture consisting of 15 to 50% v/v castor oil, and 30 to 85% v/v of medium chain triglyceride and/or propylene glycol octanoate/decanoate and/or ethyl oleate and 0 to 30% v/v of one or more of a mixture of the solvents benzyl alcohol, propylene glycol or propylene carbonate, and optionally up to 1000ppm of stabilizers.