发明名称 Thiourea inhibitors of herpes viruses
摘要 Compounds of formula (I) wherein A is heteroaryl; R9-R12 are independently hydrogen, alkyl of 1 to 4 carbon atoms, perhaloalkyl of 1 to 4 carbon atoms, halogen, alkoxy of 1 to 4 carbon atoms, or cyano, or R9 and R10 or R11 and R12 may be taken together to form aryl of 5 to 7 carbon atoms; W is O, NR6, or is absent; G is aryl or heteroaryl; and X is a bond, -NH, alkyl of 1 to 6 carbon atoms, alkenyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, thioalkyl of 1 to 6 carbon atoms, alkylamino of 1 to 6 carbon atoms, or (CH)J; and J is alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, phenyl or benzyl; and n is an integer from 1 to 6; or a pharmaceutical salt thereof, useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.
申请公布号 AU3111100(A) 申请公布日期 2000.06.26
申请号 AU20000031111 申请日期 1999.12.06
申请人 AMERICAN HOME PRODUCTS CORPORATION 发明人 JONATHAN DAVID BLOOM;MARTIN JOSEPH DIGRANDI;RUSSELL GEORGE DUSHIN;STANLEY ALBERT LANG;BRYAN MARK O'HARA
分类号 C07D295/14;A61K31/06;A61K31/075;A61K31/085;A61K31/10;A61K31/11;A61K31/136;A61K31/15;A61K31/165;A61K31/167;A61K31/17;A61K31/175;A61K31/18;A61K31/196;A61K31/215;A61K31/216;A61K31/222;A61K31/27;A61K31/275;A61K31/341;A61K31/40;A61K31/42;A61K31/426;A61K31/433;A61K31/4439;A61K31/4453;A61K31/4458;A61K31/54;A61K31/695;A61P31/12;A61P31/22;C07C335/20;C07D207/12;C07D207/14;C07D207/32;C07D207/335;C07D209/14;C07D211/22;C07D213/40;C07D213/75;C07D215/12;C07D217/12;C07D231/12;C07D231/56;C07D233/44;C07D261/08;C07D277/24;C07D277/28;C07D285/06;C07D307/52;C07D307/54;C07D333/20;C07D405/12;C07D417/12 主分类号 C07D295/14
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