4,9-Dihydro-4,9-dioxo-2-substituted-1H-naphtho[2,3]imidazole derivatives and their use in treating circulatory disorders

摘要

The specification describes use of tricyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I) for treating diseases related to venous function deficiency and/or inflammatory oedema. In general formula (I) depicted above, A is a sulphur or oxygen atom or a radical R3N where R3 is a hydrogen atom, a C1-5 alkyl radical or an optionally substituted aromatic or heteroaromatic ring; R1 is either a C1-5 alkyl radical, or a radical R4NH where R4 is a hydrogen atom, a C1-5 alkyl radical or an optionally substituted aromatic or heteroaromatic ring, or an aromatic ring optionally substituted by one or more acceptor or donor groupings, or a heteroaromatic ring having one or more heteroatoms and being optionally substituted by acceptor or donor groupings; and R2 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, an oxygen atom optionally substituted by a C1-5 alkyl radical, or a radical NR5R5', where each of R5 and R5' is independently a hydrogen or oxygen atom or C1-5 monovalent organic radicals.