摘要 |
This compound of the formula (I) is useful in the treatment of a condition selected from the group consisting of arthritis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, in combination with standard NSAID'S and analgesics and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. In formula (I) R1 and R16 each are H, alkyl, alkoxy, haloalkyl, perhaloalkyl, haloalkoxy, cycloalkylalkyl or arylalkoxyalkyl, R2 is R1 or haloalkoxy, carboxy or carboxamoyl, R3 is alkyl or aryl, R4 is H or as defined in the disclosure, R5 and R6 each are R1, alkylthio, alkylsulphinyl, or alkylsulphonyl or can be taken together to form a triple ring system with up to two hetero atoms; and Ar is an aryl or heteroaryl.
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