Intermediates for making HIV protease inhibitors

摘要

HIV protease inhibitors of the formula 1 where R1 is a heteroaryl or a group of the formula 2 where R2 is alkyl, cycloalkyl, heterocycloalkyl or O-R6 where R6 is alkyl or aralkyl or aryl; R1 can further be formula 3 where each R3 can be alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl R1 can also be formula 4 where each R4 and R5 can be alkyl, cycloalkyl, heterocycloalkyl, aryl or a heteroaryl group X is Cl Further disclosed is a method for making formula 1and final compounds like formula 5 nelfinavir mesylate.