| 摘要 |
The present invention relates to the identification of novel polypeptides that bind PKC theta and PKC zeta , termed PICOT. The invention provides PICOT polypeptides and polynucleotides and antibodies that bind to PICOT polypeptides. PICOT also has the capability of modulating activity of various polypeptides and signaling pathways, including, for example, PKC theta , PKC zeta , JNK, AP-1, NF kappa B, Trx system, HEED/WAIT-1 and production of IL-2. Thus, PICOT polypeptides, polynucleotides and antibodies of the invention are useful in modulating the activities of these polypeptides and associated signaling pathways, including for the purpose of therapeutic treatment of PICOT associated physiological conditions or disorders in a human.
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