| 摘要 |
This invention relates to methods of treatment of persons and animals with indications of immuno-deficiency, wherein the said indication is resultant from viral and/or retroviral, bacterial, fungal or parasitic infection and/or plus infectious protein units. Herein is described the method of administration of an agonist or antagonist to Th2 cytokines in combination with anti-viral agents or immune enhancing agents. In one aspect of the invention, the agonist or antagonist is a receptor to Interleukin-4 (or mutein receptor) which is administered in combination with an anti-viral agent. Preferred anti-viral/immune-enhancing agents include (a) "compounds of Formula I" (defined herein), and metabolites, analogs and precursors thereof, and pharmaceutically acceptable salts of any such compounds, metabolites, analogs and precursors, (b) protease inhibitors, and (c) reverse transcriptase inhibitors. Additionally herein is described a method of enhancing viral replication as a means of exposing latent infection by the administration of an agonist or antagonist to a Th2 cytokine. There are also provided such methods comprising administering to a patient at least one Th2 cytokine and at least one agonist and/or at least one antagonist to said Th2 cytokine. There are also provided compositions and kits for use in such methods, as well as the use of such compounds in the manufacture of medicaments for treatment for various conditions. |
