发明名称 |
HYDRONAPHTHO[2,3-c]FURAN DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
Intermediates for the preparation of himbacine exhibiting muscarinic M2 receptor antagonism, which are hydronaphtho[2,3-c]furan derivatives represented by general formula (1) or intermediates for the preparation thereof: wherein R1 is lower alkyl or aralkyl; R2 is hydrogen, lower alkyl or aralkyl; R3 and R4 together represent oxygen or methylene, or alternatively R4 is hydroxyl, lower alkoxy, aralkyloxy or lower acyloxy, with R3 being hydrogen; R5 and R6 together represent oxygen, or alternatively R6 is hydroxyl, lower alkoxy, aralkyloxy or lower acyloxy, with R5 being hydrogen; and either of the broken lines is a single bond and the other thereof is a double bond, or alternatively both are single bonds.
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申请公布号 |
WO0035898(A1) |
申请公布日期 |
2000.06.22 |
申请号 |
WO1999JP06937 |
申请日期 |
1999.12.10 |
申请人 |
SAGAMI CHEMICAL RESEARCH CENTER;KYORIN PHARMACEUTICAL CO., LTD.;TERASHIMA, SHIRO;TAKADOI, MASANORI;ISHIWATA, AKIHIRO;KATOH, TADASHI |
发明人 |
TERASHIMA, SHIRO;TAKADOI, MASANORI;ISHIWATA, AKIHIRO;KATOH, TADASHI |
分类号 |
C07D307/92;C07D493/08;C07D493/18;(IPC1-7):C07D307/92 |
主分类号 |
C07D307/92 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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