SOLUBLE COMPOSITIONS OF TRIPHENYLETHYLENE ANTIESTROGENS

摘要

The invention relates to aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxyl ic acid having 1-5 carbon atoms, wherein the carbon chain may further contain 1 -4 hydroxyl, 1-3 oxo, or one or several halogen substituents, or a correspondin g anion thereof, or methanesulfonic acid or its corresponding anion, in molar excess with respect to the triphenylethylene antiestrogen, optionally togeth er with an organic water miscible co-solvent such as polyethylene glycol (PEG), propylene glycol, ethanol or isopropanol.