| 摘要 |
It has been newly found out that ascochlorin, which is a publicly known fat- soluble antibiotic, and its homologs serve as a ligand of retinoid X recepto r and react in vivo with the amino group of serum protein to form Schiff bases without showing any side effect of retinoid. Ascochlorin and its homologs ar e usable in treating and/or preventing diseases or conditions which can be relieved by the retinoid X receptor ligand-dependent gene signal transcriptional regulation (for example, diseases caused by the expression o f insulin resistance, hypertension, cerebrovascular diseases, rheumatoid arthritis, autoimmune diseases, Ca metabolic error, complication of diabetes , arteriosclerosis, etc.). Moreover, they can inhibit denaturation and/or necrosis of pancreatic Langerhans islet .beta.-cells and, therefore, are usable in making these cells to sustain the insulin productivity.
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